Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells

We compared the effects of yeast-treated human dendritic cells (DCs) with CD40L-matured human DCs for the induction of effector cells and the number and functionality of CD4(+)CD25(+)CD127(−) FoxP3(+) regulatory T cells (Tregs). DCs were treated with yeast or CD40L and cocultured with isolated autol...

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Main Authors: Cereda, Vittore, Vergati, Matteo, Huen, Ngar-Yee, di Bari, Maria Giovanna, Jochems, Caroline, Intrivici, Chiara, Gulley, James L., Apelian, David, Schlom, Jeffrey, Tsang, Kwong Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134265/
https://ncbi.nlm.nih.gov/pubmed/21569810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.04.101
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