Upregulation of Kupffer cell α(2A)–adrenoceptors and downregulation of MKP-1 mediate hepatic injury in chronic alcohol exposure

Alcohol-induced liver disease is associated with unacceptable morbidity and mortality. When activated, Kupffer cells (KCs), the resident macrophages in the liver, release proinflammatory cytokine TNF-α, a key mediator of hepatic damage. Although chronic alcohol causes increase in norepinephrine (NE)...

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Detalhes bibliográficos
Main Authors: Ajakaiye, Michael, Jacob, Asha, Wu, Rongqian, Zhou, Mian, Ji, Youxin, Dong, Weifeng, Wang, Zhimin, Qiang, Xiaoling, Chaung, Wayne W., Nicastro, Jeffrey, Coppa, Gene F., Wang, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133744/
https://ncbi.nlm.nih.gov/pubmed/21575605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.05.007
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