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Total Synthesis of the Cyanolide A Aglycon

The synthesis of the potent molluscicide, cyanolide A, has been achieved in 10 steps without the use of protecting groups. The synthesis features a key Sakurai macrocyclization/dimerization reaction that simultaneously forms both tetrahydropyran rings and the macrocycle of the natural product.

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Detalhes bibliográficos
Main Authors: Gesinski, Michael R., Rychnovsky, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133735/
https://ncbi.nlm.nih.gov/pubmed/21639102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204228q
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