Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis

PLSCR1−/− mice exhibit normal, steady-state hematologic parameters but impaired emergency granulopoiesis upon in vivo administration of G-CSF. The mechanism by which PLSCR1 contributes to G-CSF-induced neutrophil production is largely unknown. We now report that the expansion of bone marrow myelocyt...

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Bibliografske podrobnosti
Main Authors: Chen, Chun-Wei, Sowden, Mark, Zhao, Qian, Wiedmer, Therese, Sims, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: Society for Leukocyte Biology 2011
Teme:
Spotlight on Leading Edge Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133439/
https://ncbi.nlm.nih.gov/pubmed/21447647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0111006
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