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Impaired Locomotor Learning and Altered Cerebellar Synaptic Plasticity in pep-19/pcp4-Null Mice

PEP-19/PCP4 maps within the Down syndrome critical region and encodes a small, predominantly neuronal, IQ motif protein. Pep-19 binds calmodulin and inhibits calmodulin-dependent signaling, which is critical for synaptic function, and therefore alterations in Pep-19 levels may affect synaptic plasti...

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Bibliografiske detaljer
Main Authors: Wei, Peng, Blundon, Jay A., Rong, Yongqi, Zakharenko, Stanislav S., Morgan, James I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133400/
https://ncbi.nlm.nih.gov/pubmed/21576365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05208-11
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