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FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function

The neurofibromatosis type 2 tumor suppressor protein, merlin, is related to the ERM (ezrin, radixin, and moesin) family of plasma membrane-actin cytoskeleton linkers. For ezrin, phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding to the amino-terminal FERM domain is required for its conformation...

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Bibliografiska uppgifter
Huvudupphovsmän:	Mani, Timmy, Hennigan, Robert F., Foster, Lauren A., Conrady, Deborah G., Herr, Andrew B., Ip, Wallace
Materialtyp:	Artigo
Språk:	Inglês
Publicerad:	American Society for Microbiology 2011
Ämnen:	Articles
Länkar:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3133355/ https://ncbi.nlm.nih.gov/pubmed/21402777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00609-10
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FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function

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