Defining the Strain-Dependent Impact of the Staphylococcal Accessory Regulator (sarA) on the Alpha-Toxin Phenotype of Staphylococcus aureus

We demonstrate that mutation of the staphylococcal accessory regulator (sarA) limits the accumulation of alpha-toxin and phenol-soluble modulins (PSMs) in Staphylococcus aureus isolates of the USA300 clonal lineage. Degradation assays and experiments done with protease inhibitors suggested that this...

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Detalhes bibliográficos
Main Authors: Zielinska, Agnieszka K., Beenken, Karen E., Joo, Hwang-Soo, Mrak, Lara N., Griffin, Linda M., Luong, Thanh T., Lee, Chia Y., Otto, Michael, Shaw, Lindsey N., Smeltzer, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Molecular Biology of Pathogens
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133183/
https://ncbi.nlm.nih.gov/pubmed/21478342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01517-10
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