Adoption of an “Open” Envelope Conformation Facilitating CD4 Binding and Structural Remodeling Precedes Coreceptor Switch in R5 SHIV-Infected Macaques

A change in coreceptor preference from CCR5 to CXCR4 towards the end stage disease in some HIV-1 infected individuals has been well documented, but the reasons and mechanisms for this tropism switch remain elusive. It has been suggested that envelope structural constraints in accommodating amino aci...

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Autori principali: Zhuang, Ke, Finzi, Andres, Tasca, Silvana, Shakirzyanova, Madina, Knight, Heather, Westmoreland, Susan, Sodroski, Joseph, Cheng-Mayer, Cecilia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132741/
https://ncbi.nlm.nih.gov/pubmed/21760891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021350
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