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MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1

MCM proteins are components of a DNA helicase that plays an essential role in DNA replication and cell proliferation. However, MCM proteins are present in excess relative to origins of replication, suggesting they may serve other functions. Decreased proliferation is a fundamental physiological resp...

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Autori principali: Hubbi, Maimon E., Luo, Weibo, Baek, Jin H., Semenza, Gregg L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131976/
https://ncbi.nlm.nih.gov/pubmed/21658608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.029
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