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GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria
p73, a member of the p53 family, shares high sequence homology with p53 and shows many p53-like properties: it binds to p53-DNA target sites, transactivates p53-responsive genes and induces cell cycle arrest and apoptosis. Apart from this transcription-dependent effect, less is known about the downs...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131914/ https://ncbi.nlm.nih.gov/pubmed/21127500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.153 |
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