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Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

Glutamate toxicity involves increases in intracellular calcium levels and enhanced formation of reactive oxygen species (ROS) causing neuronal dysfunction and death in acute and chronic neurodegenerative disorders. The molecular mechanisms mediating glutamate-induced ROS formation are, however, stil...

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Bibliografiska uppgifter
Huvudupphovsmän: Tobaben, S, Grohm, J, Seiler, A, Conrad, M, Plesnila, N, Culmsee, C
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131888/
https://ncbi.nlm.nih.gov/pubmed/20689558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.92
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