Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells

Cells of vertebrates remove DNA double-strand breaks (DSBs) from their genome predominantly utilizing a fast, DNA-PKcs-dependent form of non-homologous end joining (D-NHEJ). Mutants with inactive DNA-PKcs remove the majority of DNA DSBs utilizing a slow, DNA-PKcs-independent pathway that does not ut...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Wang, Huichen, Zeng, Zhao-Chong, Perrault, Ange R., Cheng, Xinbo, Qin, Wei, Iliakis, George
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31316/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11292837/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.8.1653
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