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Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes
We present an intuitive strategy for predicting the effect of sequence variation on splicing. In contrast to transcriptional elements, splicing elements appear to be strongly position dependent. We demonstrated that exonic binding of the normally intronic splicing factor, U2AF65, inhibits splicing....
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131313/ https://ncbi.nlm.nih.gov/pubmed/21685335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101135108 |
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