Lampe1: An ENU-Germline Mutation Causing Spontaneous Hepatosteatosis Identified through Targeted Exon-Enrichment and Next-Generation Sequencing

Using a small scale ENU mutagenesis approach we identified a recessive germline mutant, designated Lampe1 that exhibited growth retardation and spontaneous hepatosteatosis. Low resolution mapping based on 20 intercrossed Lampe1 mice revealed linkage to a ∼14 Mb interval on the distal site of chromos...

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Detalhes bibliográficos
Main Authors: Sheridan, Rachel, Lampe, Kristin, Shanmukhappa, Shiva Kumar, Putnam, Patrick, Keddache, Mehdi, Divanovic, Senad, Bezerra, Jorge, Hoebe, Kasper
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131302/
https://ncbi.nlm.nih.gov/pubmed/21760938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021979
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