A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma

BACKGROUND: R849 is a neurovirulent γ(1)34.5 gene-deficient form of herpes simplex virus type 1 (HSV-1) and has LacZ genes at the deleted sites of the γ(1)34.5 gene. HF is a spontaneously occurring, fusogenic HSV-1 strain. The purpose of this work was to generate a virus that has the syncytial chara...

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Bibliographic Details
Main Authors: Takaoka, Hiroo, Takahashi, Gen, Ogawa, Fumi, Imai, Tomoaki, Iwai, Soichi, Yura, Yoshiaki
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131258/
https://ncbi.nlm.nih.gov/pubmed/21663640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-294
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