Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways

The risk of developing neurodegenerative diseases increases with age. Although many of the molecular pathways regulating proteotoxic stress and longevity are well characterized, their contribution to disease susceptibility remains unclear. In this study, we describe a new Caenorhabditis elegans mode...

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Detaylı Bibliyografya
Asıl Yazarlar: Teixeira-Castro, Andreia, Ailion, Michael, Jalles, Ana, Brignull, Heather R., Vilaça, João L., Dias, Nuno, Rodrigues, Pedro, Oliveira, João F., Neves-Carvalho, Andreia, Morimoto, Richard I., Maciel, Patrícia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131043/
https://ncbi.nlm.nih.gov/pubmed/21546381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr203
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