Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways

The risk of developing neurodegenerative diseases increases with age. Although many of the molecular pathways regulating proteotoxic stress and longevity are well characterized, their contribution to disease susceptibility remains unclear. In this study, we describe a new Caenorhabditis elegans mode...

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Detalhes bibliográficos
Main Authors: Teixeira-Castro, Andreia, Ailion, Michael, Jalles, Ana, Brignull, Heather R., Vilaça, João L., Dias, Nuno, Rodrigues, Pedro, Oliveira, João F., Neves-Carvalho, Andreia, Morimoto, Richard I., Maciel, Patrícia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131043/
https://ncbi.nlm.nih.gov/pubmed/21546381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr203
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