Increased availability of angiotensin AT(1) receptors leads to sustained arterial constriction to angiotensin II in diabetes – role for Rho-kinase activation

BACKGROUND AND PURPOSE: Antagonists of angiotensin AT(1) receptors elicit beneficial vascular effects in diabetes mellitus. We hypothesized that diabetes induces sustained availability of AT(1) receptors, causing enhanced arterial constriction to angiotensin II. EXPERIMENTAL APPROACH: To assess func...

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Main Authors: Bagi, Zsolt, Feher, Attila, Cassuto, James, Akula, Komala, Labinskyy, Nazar, Kaley, Gabor, Koller, Akos
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2011
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130951/
https://ncbi.nlm.nih.gov/pubmed/21385178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01307.x
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