Increased availability of angiotensin AT(1) receptors leads to sustained arterial constriction to angiotensin II in diabetes – role for Rho-kinase activation

BACKGROUND AND PURPOSE: Antagonists of angiotensin AT(1) receptors elicit beneficial vascular effects in diabetes mellitus. We hypothesized that diabetes induces sustained availability of AT(1) receptors, causing enhanced arterial constriction to angiotensin II. EXPERIMENTAL APPROACH: To assess func...

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Hlavní autoři: Bagi, Zsolt, Feher, Attila, Cassuto, James, Akula, Komala, Labinskyy, Nazar, Kaley, Gabor, Koller, Akos
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2011
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130951/
https://ncbi.nlm.nih.gov/pubmed/21385178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01307.x
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