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Integrating energy calculations with functional assays to decipher the specificity of G-protein inactivation by RGS proteins

The diverse RGS protein family is responsible for the precise timing of G-protein signaling. To understand how RGS protein structure encodes their common ability to inactivate G-proteins and their selective G-protein recognition, we integrated structure-based energy calculations with biochemical mea...

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Hlavní autoři: Kosloff, Mickey, Travis, Amanda M., Bosch, Dustin E., Siderovski, David P., Arshavsky, Vadim Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130846/
https://ncbi.nlm.nih.gov/pubmed/21685921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2068
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