Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover

The relevance of serine 5 phosphorylation of RNA polymerase II carboxy-terminal domain during initiation has been difficult to determine in mammalian cells as no general in vivo Ser5 kinase has been identified. Here, we demonstrate that deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts...

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Autores principales: Helenius, Katja, Yang, Ying, Tselykh, Timofey V., Pessa, Heli K. J., Frilander, Mikko J., Mäkelä, Tomi P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130277/
https://ncbi.nlm.nih.gov/pubmed/21385826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr107
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