An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity

We recently characterized Winnie mice carrying a missense mutation in Muc2, leading to severe endoplasmic reticulum stress in intestinal goblet cells and spontaneous colitis. In this study, we characterized the immune responses due to this intestinal epithelial dysfunction. In Winnie, there was a fo...

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Detalhes bibliográficos
Main Authors: Eri, R D, Adams, R J, Tran, T V, Tong, H, Das, I, Roche, D K, Oancea, I, Png, C W, Jeffery, P L, Radford-Smith, G L, Cook, M C, Florin, T H, McGuckin, M A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130192/
https://ncbi.nlm.nih.gov/pubmed/21107311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2010.74
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