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Effect of nifedipine on anorectal sensorimotor functions in health and fecal incontinence

The mechanisms of increased rectal stiffness in women with fecal incontinence (FI) and rectal urgency are not understood. Our hypothesis was that distention-induced activation of mechanosensitive L-type calcium channels in smooth muscle contributes to increased rectal stiffness in FI. Anal pressures...

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Bibliographic Details
Main Authors: Bharucha, Adil E., Edge, Jessica, Zinsmeister, Alan R.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129928/
https://ncbi.nlm.nih.gov/pubmed/21493732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00557.2010
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