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Tumor necrosis factor-α is an endogenous inhibitor of Na(+)-K(+)-2Cl(−) cotransporter (NKCC2) isoform A in the thick ascending limb
The effects of TNF gene deletion on renal Na(+)-K(+)-2Cl(−) cotransporter (NKCC2) expression and activity were determined. Outer medulla from TNF(−/−) mice exhibited a twofold increase in total NKCC2 protein expression compared with wild-type (WT) mice. This increase was not observed in TNF(−/−) mic...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Physiological Society
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3129887/ https://ncbi.nlm.nih.gov/pubmed/21511694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00650.2010 |
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