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Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women

Animal studies in vivo indicate that leptin treatment in extremely leptin-sensitive ob/ob mice reduces body weight exclusively by reducing fat mass and that it increases muscle mass by downregulating myostatin expression. Data from human trials are limited. Therefore, we aimed at characterizing the...

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Bibliographic Details
Main Authors: Brinkoetter, Mary, Magkos, Faidon, Vamvini, Maria, Mantzoros, Christos S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129841/
https://ncbi.nlm.nih.gov/pubmed/21505147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00146.2011
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