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Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates

Other labs have previously reported the ability of adeno-associated virus serotype 9 (AAV9) to cross the blood-brain barrier (BBB). In this report, we carefully characterized variables that might affect AAV9's efficiency for central nervous system (CNS) transduction in adult mice, including dos...

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Detalhes bibliográficos
Main Authors: Gray, Steven J, Matagne, Valerie, Bachaboina, Lavanya, Yadav, Swati, Ojeda, Sergio R, Samulski, R Jude
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129805/
https://ncbi.nlm.nih.gov/pubmed/21487395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.72
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