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Pharmacodynamics of a Novel Designer Natriuretic Peptide, CD-NP, in a First-in-Human Clinical Trial in Healthy Subjects

CD-NP is a novel chimeric natriuretic peptide (NP) consisting of the 22-amino-acid (AA) human C-type natriuretic peptide (CNP), a venodilating peptide with limited renal actions and minimal effects on blood pressure, and the 15-AA C-terminus of Dendroaspis NP (DNP). The rationale for the design of C...

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Autors principals: Lee, Candace Y. W., Chen, Horng H., Lisy, Ondrej, Swan, Suzanne, Cannon, Courtney, Lieu, Hsiao D., Burnett, John C.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129694/
https://ncbi.nlm.nih.gov/pubmed/19395584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270009336233
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