Virally delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness

Previous work established retinal expression of channelrhodopsin-2 (ChR2), an algal cation channel gated by light, restored physiological and behavioral visual responses in otherwise blind rd1 mice. However, a viable ChR2-based human therapy must meet several key criteria: (i) ChR2 expression must b...

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Detalhes bibliográficos
Main Authors: Doroudchi, M Mehdi, Greenberg, Kenneth P, Liu, Jianwen, Silka, Kimberly A, Boyden, Edward S, Lockridge, Jennifer A, Arman, A Cyrus, Janani, Ramesh, Boye, Shannon E, Boye, Sanford L, Gordon, Gabriel M, Matteo, Benjamin C, Sampath, Alapakkam P, Hauswirth, William W, Horsager, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129568/
https://ncbi.nlm.nih.gov/pubmed/21505421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.69
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