HIF induces human embryonic stem cell markers in cancer cells

Low oxygen levels have shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors have shown to display gene expression signatures characteristic of human embryonic stem cells (hESC...

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Main Authors: Mathieu, Julie, Zhang, Zhan, Zhou, Wenyu, Wang, Amy J., Heddleston, John M., Pinna, Claudia M.A., Hubaud, Alexis, Stadler, Bradford, Choi, Michael, Bar, Merav, Tewari, Muneesh, Liu, Alvin, Vessella, Robert, Rostomily, Robert, Born, Donald, Horwitz, Marshall, Ware, Carol, Blau, C. Anthony, Cleary, Michele A., Rich, Jeremy N., Ruohola-Baker, Hannele
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129496/
https://ncbi.nlm.nih.gov/pubmed/21712410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3320
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