Invariant natural killer T cells from food allergic versus non-allergic children exhibit differential responsiveness to milk-derived sphingomyelin

BACKGROUND: A key immunological feature of food allergy (FA) is the presence of a T-helper-2 (Th2)-type cytokine bias. Ligation of the invariant natural killer T cell (iNKT) T cell receptor (TCR) by sphingolipids (SL) presented via the CD1d molecule leads to copious secretion of Th2-type cytokines....

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Main Authors: Jyonouchi, Soma, Abraham, Valsamma, Orange, Jordan S., Spergel, Jonathan M., Gober, Laura, Dudek, Emily, Saltzman, Rushani, Nichols, Kim E., Cianferoni, Antonella
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129401/
https://ncbi.nlm.nih.gov/pubmed/21458849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2011.02.026
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