RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation

Inositol 1,4,5-trisphosphate (IP(3)) receptors are endoplasmic reticulum membrane calcium channels that, upon activation, are degraded via the ubiquitin-proteasome pathway. While searching for novel mediators of IP(3) receptor processing, we discovered that RNF170, an uncharacterized RING domain-con...

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Autores principales: Lu, Justine P., Wang, Yuan, Sliter, Danielle A., Pearce, Margaret M. P., Wojcikiewicz, Richard J. H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129221/
https://ncbi.nlm.nih.gov/pubmed/21610068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.251983
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