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Detection of the G>C SNP and rare mutations in the 28-bp repeat of TYMS using gel-based capillary electrophoresis

AIMS: Polymorphisms in the 5′ regulatory region of the thymidylate synthase gene (TYMS) have been shown to modulate thymidylate synthase expression and are associated with resistance to fluoropyrimidine-based therapies. These polymorphisms include a two repeat (2R) or three repeat (3R) of a 28-bp se...

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Detalhes bibliográficos
Main Authors: Thomas, Fabienne, Hoskins, Janelle M, Dvorak, Anne, Tan, Benjamin R, McLeod, Howard L
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128643/
https://ncbi.nlm.nih.gov/pubmed/21142919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.10.170
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