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Loss of DNA Mismatch Repair Imparts a Selective Advantage in Planarian Adult Stem Cells
Lynch syndrome (LS) leads to an increased risk of early-onset colorectal and other types of cancer and is caused by germline mutations in DNA mismatch repair (MMR) genes. Loss of MMR function results in a mutator phenotype that likely underlies its role in tumorigenesis. However, loss of MMR also re...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128615/ https://ncbi.nlm.nih.gov/pubmed/21747960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021808 |
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