Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation

Mesothelin (MSLN) overexpression in pancreatic cancer (PC) leads to enhanced cell survival/proliferation and tumor progression. After screening for a number of growth factors/cytokines, we found that the MSLN expression correlated closely with interleukin (IL)-6 in human PC specimens and cell lines....

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Bibliographic Details
Main Authors: Bharadwaj, Uddalak, Marin-Muller, Christian, Li, Min, Chen, Changyi, Yao, Qizhi
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128561/
https://ncbi.nlm.nih.gov/pubmed/21515913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr075
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