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β-adrenergic receptor stimulation and activation of PKA protect against α(1)-adrenergic mediated phosphorylation of PKD and HDAC5
INTRODUCTION: Chronic activation of the β(1)-adrenergic receptor (β(1)-AR) signaling can have deleterious effects on the heart, and animal models over-expressing β(1)-ARs develop a dilated cardiomyopathy and heart failure. In the classical β-AR pathway, receptor occupancy by an agonist results in in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128428/ https://ncbi.nlm.nih.gov/pubmed/21703532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cardfail.2011.03.006 |
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