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Octamerization of λ CI repressor is needed for effective repression of P(RM) and efficient switching from lysogeny

The CI repressor of bacteriophage λ is a model for the role of cooperativity in the efficient functioning of genetic switches. Pairs of CI dimers interact to cooperatively occupy adjacent operator sites at O(R) and at O(L). These CI tetramers repress the lytic promoters and activate transcription of...

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Détails bibliographiques
Auteurs principaux: Dodd, Ian B., Perkins, Alison J., Tsemitsidis, Daniel, Egan, J. Barry
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2001
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC312832/
https://ncbi.nlm.nih.gov/pubmed/11711436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.937301
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