The set1Δ mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes

SET domain proteins are present in chromosomal proteins involved in epigenetic control of transcription. The yeast SET domain protein Set1p regulates chromatin structure, DNA repair, and telomeric functions. We investigated the mechanism by which the absence of Set1p increases DNA repair capacities...

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Autores principales: Schramke, Vera, Neecke, Holger, Brevet, Vanessa, Corda, Yves, Lucchini, Giovanna, Longhese, Maria Pia, Gilson, Eric, Géli, Vincent
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC312739/
https://ncbi.nlm.nih.gov/pubmed/11459833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.193901
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