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Receptor-Based Dosing Optimization of Erythropoietin in Juvenile Sheep after Phlebotomy

The primary objective of this work was to determine the optimal time for administration of an erythropoietin (Epo) dose to maximize the erythropoietic effect using a simulation study based on a young sheep pharmacodynamic model. The dosing optimization was accomplished by extending a Hb production p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rosebraugh, Matthew, Widness, John A., Veng-Pedersen, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127239/
https://ncbi.nlm.nih.gov/pubmed/21460232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.036855
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