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Receptor-Based Dosing Optimization of Erythropoietin in Juvenile Sheep after Phlebotomy
The primary objective of this work was to determine the optimal time for administration of an erythropoietin (Epo) dose to maximize the erythropoietic effect using a simulation study based on a young sheep pharmacodynamic model. The dosing optimization was accomplished by extending a Hb production p...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3127239/ https://ncbi.nlm.nih.gov/pubmed/21460232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.036855 |
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