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Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity

The incorporation of potentially catalytic groups in DNA is of interest for the in vitro selection of novel deoxyribozymes. A series of 10 C5-modified analogues of 2′-deoxyuridine triphosphate have been synthesised that possess side chains of differing flexibility and bearing a primary amino or imid...

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Detalhes bibliográficos
Main Authors: Lee, Sarah E., Sidorov, Alexander, Gourlain, Thierry, Mignet, Nathalie, Thorpe, Simon J., Brazier, John A., Dickman, Mark J., Hornby, David P., Grasby, Jane A., Williams, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC31265/
https://ncbi.nlm.nih.gov/pubmed/11266559
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