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Not4 E3 Ligase Contributes to Proteasome Assembly and Functional Integrity in Part through Ecm29
In this study we determine that the Not4 E3 ligase is important for proteasome integrity. Consequently, deletion of Not4 leads to an accumulation of polyubiquitinated proteins and reduced levels of free ubiquitin. In the absence of Not4, the proteasome regulatory particle (RP) and core particle (CP)...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3126335/ https://ncbi.nlm.nih.gov/pubmed/21321079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01210-10 |
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