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Herpes Simplex Virus 2 MicroRNA miR-H6 Is a Novel Latency-Associated Transcript-Associated MicroRNA, but Reduction of Its Expression Does Not Influence the Establishment of Viral Latency or the Recurrence Phenotype

The herpes simplex virus 2 (HSV-2) viral microRNA (miRNA) designated miR-H6 is located upstream of the latency-associated transcript (LAT) promoter region on the strand opposite the LAT. Deletion of the LAT promoter and part of LAT exon 1 abolished HSV-2 miR-H6 expression in acutely and latently inf...

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Detalhes bibliográficos
Main Authors: Tang, Shuang, Bertke, Andrea S., Patel, Amita, Margolis, Todd P., Krause, Philip R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126258/
https://ncbi.nlm.nih.gov/pubmed/21325410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01997-10
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