The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo

Retinoic acid (RA), a derivative of vitamin A, plays a pivotal role in vertebrate development. The level of RA may be determined by the balance between its synthesis and degradation. We have examined the role of CYP26, a P450 enzyme that may degrade RA, by generating mutant mice that lack CYP26. CYP...

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Main Authors: Sakai, Yasuo, Meno, Chikara, Fujii, Hideta, Nishino, Jinsuke, Shiratori, Hidetaka, Saijoh, Yukio, Rossant, Janet, Hamada, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC312617/
https://ncbi.nlm.nih.gov/pubmed/11157777
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