Phosphatase Resistant Gap Junctions Inhibit Pathologic Remodeling and Prevent Arrhythmias

RATIONALE: Post-translational phosphorylation of connexin43 (Cx43) has been proposed as a key regulatory event in normal cardiac gap junction expression and pathologic gap junction remodeling. Nonetheless, the role of Cx43 phosphorylation in the context of the intact organism is poorly understood. O...

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Main Authors: Remo, Benjamin F., Qu, Jiaxiang, Volpicelli, Frank M., Giovannone, Steven, Shin, Dan, Lader, Joshua, Liu, Fang-yu, Zhang, Jie, Lent, Danielle S., Morley, Gregory E., Fishman, Glenn I.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126103/
https://ncbi.nlm.nih.gov/pubmed/21527737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.244046
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