Beyond KRAS: perspectives on new potential markers of intrinsic and acquired resistance to epidermal growth factor receptor inhibitors in metastatic colorectal cancer

The monoclonal antibodies cetuximab and panitumumab, directed against the epidermal growth factor receptor (EGFR), are licensed for the treatment of KRAS wild-type metastatic colorectal cancer (mCRC). Such ‘molecular restriction’ derived from post-hoc analyses of randomized trials and from other ret...

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Bibliografiske detaljer
Main Authors: Loupakis, Fotios, Cremolini, Chiara, Fontanini, Gabriella, Stasi, Irene, Salvatore, Lisa, Falcone, Alfredo
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2009
Fag:
Reviews
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126002/
https://ncbi.nlm.nih.gov/pubmed/21789120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758834009348984
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