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Tryptophan Prototrophy Contributes to Francisella tularensis Evasion of Gamma Interferon-Mediated Host Defense

Francisella tularensis is able to survive and replicate within host macrophages, a trait that is associated with the high virulence of this bacterium. The trpAB genes encode the enzymes required for the final two steps in tryptophan biosynthesis, with TrpB being responsible for the conversion of ind...

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Autori principali: Chu, Ping, Rodriguez, Annette R., Arulanandam, Bernard P., Klose, Karl E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125836/
https://ncbi.nlm.nih.gov/pubmed/21464086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01349-10
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