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Polygenic Modeling of Genome-Wide Association Studies: An Application to Prostate and Breast Cancer

Genome-wide association studies (GWAS) have successfully detected and replicated associations with numerous diseases, including cancers of the prostate and breast. These findings are helping clarify the genomic basis of such diseases, but appear to explain little of disease heritability. This limita...

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Detalhes bibliográficos
Main Authors: Witte, John S., Hoffmann, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125548/
https://ncbi.nlm.nih.gov/pubmed/21348634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/omi.2010.0090
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