The Leydig Cell MEK/ERK Pathway Is Critical for Maintaining a Functional Population of Adult Leydig Cells and for Fertility

MAPK kinase (MEK)1 and MEK2 were deleted from Leydig cells by crossing Mek1(f/f);Mek2(−/−) and Cyp17iCre mice. Primary cultures of Leydig cell from mice of the appropriate genotype (Mek1(f/f);Mek2(−/−);iCre(+)) show decreased, but still detectable, MEK1 expression and decreased or absent ERK1/2 phos...

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Detalhes bibliográficos
Main Authors: Yamashita, Soichi, Tai, Ping, Charron, Jean, Ko, CheMyong, Ascoli, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125090/
https://ncbi.nlm.nih.gov/pubmed/21527500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-0059
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