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Systems pharmacology assessment of the 5-fluorouracil pathway

AIM: To assess the impact of the 5-fluorouracil (5-FU) drug-pathway genes on cytotoxicity, and determine whether loss-of-function analyses coupled with functional assays can help prioritize pharmacogenomic candidate genes. MATERIALS & METHODS: Dose-response experiments were used to quantify the...

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Main Authors: Muhale, Filipe A, Wetmore, Barbara A, Thomas, Russell S, McLeod, Howard L
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124653/
https://ncbi.nlm.nih.gov/pubmed/21449674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.10.188
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