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Sirtuin-1 regulation of mammalian metabolism

Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on data obtained in vivo, we review how SirT1 orchestrates the adaptive response to fasting by stimulating hepatic...

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Detalhes bibliográficos
Main Authors: Gillum, Matthew P., Erion, Derek M., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123438/
https://ncbi.nlm.nih.gov/pubmed/20971038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2010.09.005
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