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Sirtuin-1 regulation of mammalian metabolism
Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on data obtained in vivo, we review how SirT1 orchestrates the adaptive response to fasting by stimulating hepatic...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3123438/ https://ncbi.nlm.nih.gov/pubmed/20971038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2010.09.005 |
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