Determinants of Sensitivity to DZNep Induced Apoptosis in Multiple Myeloma Cells

The 3-Deazaneplanocin A (DZNep), one of S-adenosylhomocysteine (AdoHcy) hydrolase inhibitors, has shown antitumor activities in a broad range of solid tumors and acute myeloid leukemia. Here, we examined its effects on multiple myeloma (MM) cells and found that, at 500 nM, it potently inhibited grow...

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Bibliographic Details
Main Authors: Xie, Zhigang, Bi, Chonglei, Cheong, Lip Lee, Liu, Shaw Cheng, Huang, Gaofeng, Zhou, Jianbiao, Yu, Qiang, Chen, Chien-Shing, Chng, Wee Joo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123372/
https://ncbi.nlm.nih.gov/pubmed/21720561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021583
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