Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

BACKGROUND: A subset of lung cancer patients harbour EGFR somatic mutations in their tumours and are candidates for treatment with EGFR tyrosine kinase inhibitors. In a few cases EGFR mutations have also been found in the germ line, suggesting a role in lung carcinogenesis. Objetives of this study w...

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Hlavní autoři: Centeno, Irene, Blay, Pilar, Santamaría, Iñigo, Astudillo, Aurora, Pitiot, Ana S, Osorio, Fernando G, González-Arriaga, Patricia, Iglesias, Fernando, Menéndez, Primitiva, Tardón, Adonina, Freije, Jose M, Balbín, Milagros
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123322/
https://ncbi.nlm.nih.gov/pubmed/21575252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-172
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